Action of Escherichia coli heat-stable enterotoxin II on isolated sections of mouse ileum |
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Authors: | Shunji Hitotsubashi Masaaki Akagi Akihiko Saitou Hiroyasu Yamanaka Uoshio Fujii Keinosuke Okamoto |
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Affiliation: | Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan. |
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Abstract: | When Escherichia coli STII was applied to the serosa of the ileum at a concentration of 40 micrograms/ml, an acceleration of the spontaneous motility and a weak contraction were induced 2-3 min later. The induction was not affected by the addition of atropine (10(-6) M), but was abolished by the addition of papaverine (10(-4) M). When STII was applied to the mucosa, the acceleration of the spontaneous motility appeared 7-8 min later, but a contraction was not induced. These results suggest that STII acts directly on muscle cell of the ileum and enhances the spontaneous motility of the intestine. |
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