Role of gammadelta T cells in protecting normal airway function |
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Authors: | Willi K Born Michael Lahn Katsuyuki Takeda Arihiko Kanehiro Rebecca L O'Brien Erwin W Gelfand |
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Institution: | National Jewish Medical and Research Center, Denver, Colorado 80206, USA. |
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Abstract: | Since their discovery 15 years ago, the role of gammadelta T cells has remained somewhat elusive. Responses of gammadelta T cells have been found in numerous infectious and non-infectious diseases. New evidence points to gammadelta T cells' functioning in the airways to maintain normal airway responsiveness or tone. In the lung, distinct subsets of gammadelta T cell subsets seem to have specific roles, one subset promoting allergic inflammation, the other serving a protective role. |
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