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7-Silylcamptothecins (silatecans): A new family of camptothecin antitumor agents |
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| Authors: | Hubert Josien David Bom Dennis P. Curran Yu-Huang Zheng Ting-Chao Chou |
| Affiliation: | Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA Laboratory of Biochemical Pharmacology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10021, USA |
| Abstract: | The synthesis and biological evaluation of about one dozen 7-silylcamptothecin derivatives are described. Most new compounds show potencies comparable to or better than camptothecin itself. The best compound, 11-fluoro-10-amino-7-trimethylsilylcamptothecin, is more than 20 times more potent than camptothecin in cell assays. |
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