In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series |
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| Authors: | Nersesian Diana L Black Lawrence A Miller Thomas R Vortherms Timothy A Esbenshade Timothy A Hancock Arthur A Cowart Marlon D |
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| Affiliation: | Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. diana.nersesian@abbott.com |
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| Abstract: | Structure-activity relationships (SAR) were analyzed within a library of diverse yet simple compounds prepared as histamine H3 antagonists. The libraries were constructed with a variety of low molecular weight pyrrolidines, selected from (R)-2-methylpyrrolidine, (S)-2-methylpyrrolidine, and pyrrolidine. |
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