A convenient synthesis of the side chain of loteprednol etabonate--an ocular soft corticosteroid from 20-oxopregnanes using metal-mediated halogenation as a key reaction |
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| Authors: | Chowdhury Pritish Borah Juri Moni Goswami Papori Das Archana Moni |
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| Affiliation: | Natural Products Chemistry Division, North East Institute of Science & Technology, Jorhat 785 006, Assam, India |
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| Abstract: | A facile synthesis of the side chain of loteprednol etabonate, namely, chloromethyl-17α-[(ethoxycarbonyl))oxy]-11β-hydro of loteprednol etabonate, viz., chloromethyl-17α-[(ethoxycarbonyl))oxy]-11xy-3-oxoandrosta-1,4-diene-17β-carboxylate - an ocular soft corticosteroid, has been described starting from a 20-oxopregnane, namely, 3β-acetoxy-pregn-5(6),16(17)-diene-20-one (16-dehydropregnenolone acetate, i.e., 16-DPA) using our recently developed metal-mediated halogenation as a key reaction. |
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| Keywords: | Loteprednol etabonate Soft corticosteroid 16-DPA Metal mediated halogenation Anti-inflammatory agents |
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