Improved responsiveness and reduced sample size requirements of PROMIS physical function scales with item response theory |
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| Authors: | James F Fries Eswar Krishnan Matthias Rose Bharathi Lingala Bonnie Bruce |
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| Institution: | (1) Department of Medicine, Stanford University School of Medicine, 1000 Welch Road, Suite 203, Palo Alto, CA 04304, USA;(2) University of Massachusetts Boston, 100 Morrissey Blvd, Boston, MA 02125-3393, USA |
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| Abstract: | Introduction The Health Assessment Questionnaire Disability Index (HAQ) and the SF-36 PF-10, among other instruments, yield sensitive and
valid Disability (Physical Function) endpoints. Modern techniques, such as Item Response Theory (IRT), now enable development
of more precise instruments using improved items. The NIH Patient Reported Outcomes Measurement Information System (PROMIS)
is charged with developing improved IRT-based tools. We compared the ability to detect change in physical function using original
(Legacy) instruments with Item-Improved and PROMIS IRT-based instruments. |
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