Towards an ecdysone synthesis. 20 -acetoxy-5 -pregna-2,7-dien-6-one |
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| Authors: | W B Smith G P Newsoroff N Y Wu |
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| Affiliation: | Department of Chemistry Texas Christian University Fort Worth, Texas 76129 USA |
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| Abstract: | Pregnenolone (3β-hydroxy-5-pregnen-20-one) was converted to 20β-acetoxy-3, 5-cyclo-5α-pregnan-6-one by existing procedures. This compound was ring opened with bromine, and the resultant 3, 5-dibromide was subsequently rearranged to the 3, 7-dibromide. Dehydrohalogenation of the latter gave 20β-acetoxy-5α-pregna-2, 7-dien-6-one. This substance is of interest as intermediate for the synthesis of ecdysone. |
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