Insights from the Genome Sequence of a Salmonella enterica Serovar Typhi Strain Associated with a Sporadic Case of Typhoid Fever in Malaysia |
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Authors: | Kien-Pong Yap Cindy Shuan Ju Teh Ramani Baddam Lay-Ching Chai Narender Kumar Tiruvayipati Suma Avasthi Niyaz Ahmed Kwai-Lin Thong |
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Affiliation: | Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia. |
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Abstract: | Salmonella enterica serovar Typhi is the causative agent of typhoid fever, which causes nearly 21.7 million illnesses and 217,000 deaths globally. Herein, we describe the whole-genome sequence of the Salmonella Typhi strain ST0208, isolated from a sporadic case of typhoid fever in Kuala Lumpur, Malaysia. The whole-genome sequence and comparative genomics allow an in-depth understanding of the genetic diversity, and its link to pathogenicity and evolutionary dynamics, of this highly clonal pathogen that is endemic to Malaysia. |
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