冷习服大鼠血管内皮细胞适应性改变与抗冻能力的研究

本文观测了冷习服大鼠及其冻伤后血管内皮细胞（ＶＥＣ）的某些功能的变化。结果表明，与未习服组比，冷习服鼠循环血中ＶＥＣ计数显著增加，血中６－ｋｅｔｏ－ＰＧＦ１α和ＴＸＢ２含量明显升高，而Ｔ／Ｐ比值接近，血清血管紧张素Ⅰ转换酶（ＡＣＥ）活性减低。冻伤后未习服组这些指标除ＡＣＥ显著降低外，其余均急剧升高；而冷习服组仅见短暂轻微的改变或改变不明显，且其冻足组织活存面积亦显著增加。表明冷习服后，ＶＥＣ发生了代谢更新率加快、功能增强的适应性改变，有利于提高机体对寒冷损伤的应激和修复能力

THE ADAPTIVE CHANGES IN VASCULAR ENDOTHELIAL CELL AND RESISTANCE TO FROSTBITE IN COLD ACCLIMATED RATS

Several functions of vascular endothelial cells (VEC) were investigated in rats acclimated to cold (CA) and with frostbitten feet. The results indicated that in CA rats, the number of endothelial cells in circulatory blood and the contents of 6-keto -PGF1 alpha and TXB2 in plasma were markedly higher, the activity of serum angiotensin I converting enzyme (ACE) was lower, compared with those in rats non-acclimated to cold (NCA), whereas T/P ratio of the two groups was close to each other. After the rats were frostbitten, those parameters in NCA group increased sharply except for a decrease in ACE activity. But in CA group, those parameters decreased temporarily or did not change obviously and the tissue survival area (TSA) significantly increased. The above findings suggest that the adaptive changes in increase of metabolic turnover rate and function of VEC after cold acclimation may be beneficial to the body to enhance the resistance to frostbite and repairing ability.