| 清醒无拘束豚鼠气道反应性测定方法 |
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| 引用本文： | 魏尔清,张纬萍.清醒无拘束豚鼠气道反应性测定方法[J].中国应用生理学杂志,1997,13(1):86-88. |
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| 作者姓名： | 魏尔清 张纬萍 |
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| 作者单位： | 浙江医医科大学药理学教研室、神经生物学实验室 |
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| 摘 要： | 本实验建立了清醒无拘束豚鼠气道反应性的测定方法，具有简便、稳定、可定量研究的特点。清醒豚鼠吸入组胺（Ｈｉｓ）和乙酰胆碱（ＡＣｈ）后的引喘作用有浓度依赖性，半数有效引喘浓度（ＥＣ５０）分别为５３．５μｍｏｌ／ｍ３和２６９μｍｏｌ／ｍ３。
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| 关 键 词： | 气道反应性 组胺 乙酰胆碱 |
DETERMINATION OF AIRWAY REACTIVITY IN THE CONSCIOUS AND UNRESTRAINED GUINEA PIGS |
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| Wei Erqing,Zhang Weiping,Lu Zhiyong,Wu Renyi,Ju Xingyao,Bian Rulian.DETERMINATION OF AIRWAY REACTIVITY IN THE CONSCIOUS AND UNRESTRAINED GUINEA PIGS[J].Chinese Journal of Applied Physiology,1997,13(1):86-88. |
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| Authors: | Wei Erqing Zhang Weiping Lu Zhiyong Wu Renyi Ju Xingyao Bian Rulian |
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| Institution: | Department of Pharmacology, Zhejiang Medical University, Hangzhou. |
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| Abstract: | A simple, stable determining system in the conscious and unrestrained guinea pigs was established that can quantitatively analyse the airway reactivity (AR). In this model, the response to histamine (His) or acetylcholine (ACh) aerosol was concentration-dependent with EC50 effective concentration causing 50% animals wheezing) of 53.3 mumol/m3 and 269 mumol/m3 respectively. |
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| Keywords: | airway reactivity histamine acetylcholine |
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