| 大鼠实验性血栓模型的建立及其评价 |
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| 引用本文： | 徐晖,朱妙章.大鼠实验性血栓模型的建立及其评价[J].中国应用生理学杂志,1997,13(1):89-90. |
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| 作者姓名： | 徐晖 朱妙章 |
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| 作者单位： | 第四军医大学生理学教研室，西安交通大学生物力学室 |
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| 基金项目： | 日本Uchida国际研究基金 |
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| 摘 要： | 根据Ｖｉｒｃｈｏｗ血栓形成原理，采用机械性损伤内膜，同时降低血流速度方法制备大鼠实验性血栓模型。结果显示，利用此方法制备血栓模型成功率为７８．４％，血栓平均长度８．５３±１．４２ｍｍ，血栓形成后，腹主动脉的收缩功能明显下降。
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| 关 键 词： | 血栓 血栓形成 动物模型 |
THE ESTABLISHMENT AND EVALUATION OF ABDOMINAL AORTA THROMBOSIS MODEL IN RAT |
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| Xu Hui,Zhu Miaozhang,Pei Jianmin,Zang Yimin,Han Haichao.THE ESTABLISHMENT AND EVALUATION OF ABDOMINAL AORTA THROMBOSIS MODEL IN RAT[J].Chinese Journal of Applied Physiology,1997,13(1):89-90. |
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| Authors: | Xu Hui Zhu Miaozhang Pei Jianmin Zang Yimin Han Haichao |
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| Institution: | Department of Physiology, 4th Military Medical University, Xian. |
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| Abstract: | An animal model of abdominal aorta thrombosis based on Virchow's thrombosis principle was induced by endothelium denudation with a polyethylene catheter combining severe stenosis with an aortic constriction in rats. A total of 37 rats were involved in thrombosis induction. Among them thrombus developed in 27 rats. Mean length of thrombus was 8.53 +/- 1.42 mm. The contractibility of vascular wall in the thrombotic group significantly reduced. |
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