| 饥饿状态大鼠胰腺高血糖素和胰岛素变化的定量分析 |
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| 引用本文： | 陈丽华 张元强. 饥饿状态大鼠胰腺高血糖素和胰岛素变化的定量分析[J]. 中国应用生理学杂志, 1997, 13(4): 359-360 |
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| 作者姓名： | 陈丽华 张元强 |
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| 摘 要： | 用免疫组织化学方法结合图象分析技术对饥饿状态大鼠胰岛Ａ、Ｂ细胞中胰因糖素和胰岛素的免疫反应强度进行定量分析。结果表明：与正常对照相比，饥饿大鼠胰岛细胞中的Ｇｌｕ含量明显下降，Ｂ细胞中Ｉｎｓ含量明显升高。提示饥饿可导致Ｇｌｕ释放增加，Ｉｎｓ和减少。与饥饿５天大鼠线要比较，饥饿５天后静脉注射葡萄糖组９０ｍｉｎ后胰岛内Ｇｌｕ含量明显升高，Ｉｎｓ含量无显著变化。提示：静脉注射葡萄糖要快速作用下胰岛Ａ细胞，
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| 关 键 词： | 胰岛 饥饿 胰岛素 胰高血糖素 |
Quantitative change of glucagon and insulin immunoreactivities in the pancreas of fasting rats] |
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| L Chen,Y Zhang,Y Cao,H Su. Quantitative change of glucagon and insulin immunoreactivities in the pancreas of fasting rats][J]. Chinese journal of applied physiology, 1997, 13(4): 359-360 |
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| Authors: | L Chen Y Zhang Y Cao H Su |
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| Affiliation: | Department of Histology and Embryology, Fourth Military Medical University, Xi'an. |
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| Abstract: | In this study, the glucagon and insulin immunoreactivities in the fasting rat pancreas were quantitated by image analysis. The results showed that the glucagon immunoreactivity significantly decreased in fasting rats and that of insulin increased, as compared with that in normal rats. The glucagon immunoreactivity significantly increased after intravenous injection of glucose but no marked difference was found in insulin. These results suggest that the A cells of pancreas may be directly stimulated by nutrients, and the B cells in a different way. |
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