| Acetyl—DL—leucine对猫单侧前庭神经切断后运动平衡能力和前庭外… |
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| 引用本文： | 孙久荣. Acetyl—DL—leucine对猫单侧前庭神经切断后运动平衡能力和前庭外…[J]. 中国应用生理学杂志, 1997, 13(3): 257-260 |
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| 作者姓名： | 孙久荣 |
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| 摘 要： | 本文观测了Ａｃｅｔｙｌ－ＤＬ－ｌｅｕｃｉｎｅ对猫单侧前庭神经切断后前庭代偿的影响。结果显示；ＡＬ加快术后猎在转动横梁测试中运动平衡能力的恢复，但抑制去传入前庭外侧核神经元静息自发放电频率的恢复。ＡＬ促进放电活动与头部左右动体位相关的神经元数量和比例的恢复，从术后的第１周的１０％，逐渐提高到术后第３周的６０％。第５周的７５％。
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| 关 键 词： | 前庭神经损伤 运动平衡 神经元放电 抗眩晕药 |
Effects of acetyl-DL-leucine on the recovery of the locomotor equilibrium and spontaneous discharge of lateral vestibular nucleus neurons in unilateral vestibular neurectomized cats] |
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| J Sun. Effects of acetyl-DL-leucine on the recovery of the locomotor equilibrium and spontaneous discharge of lateral vestibular nucleus neurons in unilateral vestibular neurectomized cats][J]. Chinese journal of applied physiology, 1997, 13(3): 257-260 |
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| Authors: | J Sun |
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| Affiliation: | Department of Physiology and Biophysics, College of Life Sciences, Peking University, Beijing. |
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| Abstract: | The effects of acetyl-DL-leucine (AL) treatment (28 mg/kg.day, p.o.) on the vestibular compensation were studied over period of 6 weeks in unilateral vestibular neurectomized cats. This investigation was performed by measuring the recovery time of locomotor equilibrium in the rotating beam test and recording the unitary extracellular activity of single neurons of lateral vestibular nucleus (LVN) in totally awake cats. The results showed that AL treatment strongly accelerated the recovery of locomotor equilibrium and significantly inhibited the recovery of resting spontaneous firing rate within the deafferented LVN neurons (n = 506) but improved the sensitivity and recovery of relative amount and proportion of neurons (n = 454) in response to head roll tilts in frontal plane. The neurophysiological mechanisms of AL role in the vestibular compensation were discussed. |
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