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Solid-phase synthesis of FKBP12 inhibitors: N-sulfonyl and N-carbamoylprolyl/pipecolyl amides |
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| Authors: | Wei Ling Wu Yon- Qian Wilkinson Douglas E Chen Yi Soni Raj Scott Chad Ross Douglas T Guo Hong Howorth Pamela Valentine Heather Liang Shi Spicer Dawn Fuller Mike Steiner Joseph Hamilton Gregory S |
| Affiliation: | Guilford Pharmaceuticals Inc., Research Department, 6611 Tributary Street, 21224, Baltimore, MD, USA |
| Abstract: | In parallel with our work on solution-phase parallel synthesis of ligands for the rotamase enzyme FKBP12, we herein report a methodology for the solid-phase synthesis of two classes of inhibitor, N-sulfonyl and N-carbamoylprolyl and pipecolyl amides along with their in vitro/in vivo biological results. |
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