Tracking microdomain dynamics in cell membranes |
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| Authors: | Charles A Day |
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| Institution: | a Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
b Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA |
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| Abstract: | Studies of the diffusion of proteins and lipids in the plasma membrane of cells have long pointed to the presence of membrane domains. A major challenge in the field of membrane biology has been to characterize the various cellular structures and mechanisms that impede free diffusion in cell membranes and determine the consequences that membrane compartmentalization has on cellular biology. In this review, we will provide a brief summary of the classes of domains that have been characterized to date, focusing on recent efforts to identify the properties of lipid rafts in cells through measurements of protein and lipid diffusion. |
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| Keywords: | Membrane microdomain Lipid raft Lateral diffusion Fluorescence recovery after photobleaching Fluorescence correlation spectroscopy Single particle tracking |
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