| OSCA/TMEM63家族离子通道的研究进展 |
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| 引用本文： | 吴惊香,陈雷. OSCA/TMEM63家族离子通道的研究进展[J]. 生物化学与生物物理进展, 2020, 47(2): 123-130 |
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| 作者姓名： | 吴惊香 陈雷 |
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| 作者单位： | 北京大学分子医学所,北京大学分子医学所 |
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| 基金项目： | 中国科技部重点研发计划（2016YFA0502004）,国家自然科学基金（91957201,31622021,31870833 和31821091）,北京市自然科学基金（5192009）和千人计划 |
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| 摘 要： | 高渗促钙内流蛋白(hyperosmolality-induced [Ca2+]iincrease,OSCA)/跨膜蛋白63 (transmembrane protein 63,TMEM63)家族蛋白是一类多次跨膜蛋白质,它们在真核细胞中有广泛分布.研究表明拟南芥中OSCA1.1蛋白介导了高渗刺激的钙离子内流.进一步研究发现OSCA1.1及其同源蛋白质是机械力敏感的离子通道.高分辨率冷冻电镜结构显示OSCA蛋白是对称的二聚体,每个亚基含有一个离子可通透的孔道.本文将从OSCA通道的功能、结构以及结构与功能的关系几方面介绍该领域的研究进展.
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| 关 键 词： | 高渗促钙内流蛋白 跨膜蛋白63 机械力敏感的离子通道 跨膜蛋白16 似跨膜通道蛋白 |
| 收稿时间： | 2019-10-18 |
| 修稿时间： | 2019-11-20 |
Recent Progress on The Studies of OSCA/TMEM63 Family Ion Channels |
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| WU Jing-Xiang and CHEN Lei. Recent Progress on The Studies of OSCA/TMEM63 Family Ion Channels[J]. Progress In Biochemistry and Biophysics, 2020, 47(2): 123-130 |
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| Authors: | WU Jing-Xiang and CHEN Lei |
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| Affiliation: | Institute of Molecular Medicine, Peking University,Institute of Molecular Medicine, Peking University |
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| Abstract: | Hyperosmolality-induced [Ca2+]i increase (OSCA)/Transmembrane protein 63 (TMEM63) family proteins are multi-pass membrane proteins. They are broadly present in eukaryotic cells. Previous study shows that OSCA1.1 from arabidopsis mediates the hyperosmolality induced calcium increase in plants. Additional studies show OSCA1.1 and its homologues are mechanosensitive ion channels. High resolution cryo-EM structures reveal that OSCA proteins are symmetric dimers and each subunit harbors an ion permeation pathway. The review will focus on recent progress on the studies of the function, structure and structural-functional relationship of OSCA channels. |
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| Keywords: | OSCA TMEM63 mechanosensitive ion channel TMEM16 TMC |
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