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葛根素对2型糖尿病大鼠的治疗作用*
引用本文:杨飞,董昕昕,郭赟. 葛根素对2型糖尿病大鼠的治疗作用*[J]. 中国应用生理学杂志, 2019, 35(4): 355-358. DOI: 10.12047/j.cjap.5786.2019.075
作者姓名:杨飞  董昕昕  郭赟
作者单位:1. 中国人民武装警察部队特色医学中心内分泌科, 天津 300162;2. 中国人民武装警察部队特色医学中心肿瘤外科, 天津 300162
基金项目:*武警后勤学院附属医院青年基金(WHJ2016018)
摘    要:目的:观察葛根素对2型糖尿病(T2DM)大鼠的治疗作用。方法:采用高糖高脂饲料喂养加一次性腹腔注射60 mg/kg链脲佐菌素的方法建立T2DM 大鼠模型,随机分为正常组,模型组,二甲双胍(40 mg/kg)组,葛根素低、中、高剂量(40,80,160 mg/kg)组,每组10只大鼠;造模成功后,灌胃给药4周,每周测量大鼠体重和空腹血糖(FBG),末次给药24 h后取血,收集血清,检测各组大鼠的血糖、血清甘油三酯(TG)、总胆固醇(TC) 、低密度脂蛋白-胆固醇(LDL-C)水平、高密度脂蛋白-胆固醇(HDL-C),血清天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)活性,血清尿素氮(BUN)、肌酐(SCr)、尿酸(UA)水平。结果:干预4周后,与正常组比较,模型组大鼠体重显著降低(P<0.01),FBG,TC,TG,LDL-C,ALT,AST,BUN,SCr,UA均显著升高(P<0.01),而HDL-C 显著降低(P<0.01);与模型组比较,二甲双胍组和葛根素各剂量组大鼠体重均显著增加(P<0.01),FBG,TC,TG,LDL-C,ALT,AST,BUN,SCr,UA均显著降低(P<0.01),而HDL-C显著升高(P<0.01)。结论:葛根素能够减少T2DM大鼠体重降低幅度,降低血脂、血糖水平,可用于T2DM的治疗。

关 键 词:葛根素  2型糖尿病  血糖  血脂  大鼠  
收稿时间:2018-11-20

Effects of puerarin on rats with type 2 diabetes mellitus
YANG Fei,DONG Xin-xin,GUO Yun. Effects of puerarin on rats with type 2 diabetes mellitus[J]. Chinese journal of applied physiology, 2019, 35(4): 355-358. DOI: 10.12047/j.cjap.5786.2019.075
Authors:YANG Fei  DONG Xin-xin  GUO Yun
Affiliation:1. Department of Endocrinology, Characteristic Medical Center of the Chinese People’s Armed Police Force, Tianjin 300162;2. Department of Surgical Oncology, Characteristic Medical Center of the Chinese People’s Armed Police Force, Tianjin 300162, China
Abstract:Objective: To investigate the therapeutic effects of puerarin on rats with type 2 diabetes mellitus (T2DM). Methods: T2DM models were established by high fat and high glucose feeding combined with a one-time intraperitoneal injection of streptozotocin (STZ, 60 mg/kg). Then the rats were randomly divided into normal group, model group, metformin group (MET, 40 mg/kg), puerarin low-dose group, medium-dose group and high-dose group (40, 80, 160 mg/kg), n=10. After the model was successfully established, rats were treated with corresponding drug intervention by intragastrical administration for 4 weeks. The body weight and fasting blood glucose (FBG) were measured per week, and blood samples were collected 24 h after the last administration, and serum levels of blood glucose, serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholestrol (HDL-C), serum enzyme activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), serum creatinine (SCr), and blood uric acid (UA) were measured. Results: As compared with normal group, the body weight was decreased after 4 weeks-intervention in the model group, and the levels of FBG, TC, TG, LDL-C, ALT, AST, BUN, SCr and UA were all increased,while HDL-C level was decreased (P<0.05). As compared with model group,the body weight was increased after 4 weeks-intervention in metformin group and puerarin groups, and the levels of FBG, TC, TG, LDL-C, ALT, AST, BUN, SCr and UA were decreased (P<0.01); meanwhile, HDL-C level was increased significantly (P<0.05). Conclusion: Puerarin can reduce the weight loss of T2DM rats, decrease the blood lipid and blood glucose levels of T2DM rats, which can be used to control T2DM.
Keywords:puerarin  type 2 diabetes mellitus  blood glucose  blood lipid  rat  
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