IL-21 is associated with natural resistance to HIV-1 infection in a Colombian HIV exposed seronegative cohort |
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| Institution: | 1. Department of Biomedical and Clinical Sciences ‘L. Sacco’, University of Milan, Milan, Italy;2. Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Medellín, Colombia;1. Department of Microbiology and Infectious Diseases, Faculty of Medicine, Toho University Graduate School of Medicine, Tokyo, 143-8540, Japan;2. First Department of Internal Medicine, Hokkaido University Hospital, Hokkaido, 060-8638, Japan;3. Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 48105, USA;4. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, 48105, USA;1. Department of Parasitology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil;2. Department of Physics, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil;3. School of Medical Sciences, Universidade Federal de Mato Grosso, Cuiabá, MT, 78060-900, Brazil;1. Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, Queensland, Australia;2. Faculty of Veterinary Medicine, Chattogram Veterinary and Animal Sciences University, Chattogram, Bangladesh;3. Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns & Townsville, Queensland, Australia;4. College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland, Australia;5. University of New England, New South Wales, Australia |
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| Abstract: | Higher IL-21 levels were associated with natural resistance to HIV infection in an Italian cohort. Thus we wanted to confirm such association in HIV exposed seronegative individuals (HESN) from Colombia. Cells from HESN were less susceptible to infection and expressed higher IL-21 mRNA levels than healthy controls at both baseline and 7-days post-infection; similar results were observed for IL-6, perforin, and granzyme. These results suggest that IL-21/IL-6 increase may be a distinctive quality in the profile of HIV-1 resistance, at least during sexual exposure. However, further studies are necessary to confirm the specific protective mechanisms of these cytokines. |
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| Keywords: | HIV HIV natural resistance IL-21 HESN |
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