Influence of bone mineral density in circulating adipokines among postmenopausal Arab women |
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Institution: | 1. Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia;2. Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11451, Saudi Arabia;3. Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium |
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Abstract: | Osteoporosis and osteopenia has a significant link with substantial fracture risk. Epidemiological data revealed a protective role of adipose tissue on bone biology in postmenopausal osteoporosis. The current study assessed the associations between select adipokines and bone mineral density (BMD) in postmenopausal women. A total of 175 Saudi postmenopausal women were selected and categorized based on their BMD (normal & low-BMD). Circulating levels of select adipokines (adiponectin, resistin, leptin, and adipsin), insulin, 25(OH)D and RANKl were determined using commercially available assay kits. BMD was measured by dual-energy X-ray absorptiometry (DXA). Overall and among low-BMD subjects, adiponectin consistently showed a significant inverse association with BMD (overall ?0.34, p < 0.01; low BMD group ?0.34, p < 0.01). In multiple regression, adiponectin (?0.29 ± 0.06, p < 0.00) and resistin (?0.08 ± 0.04, p < 0.05) were inversely significant with BMD overall, but after stratification the significance was lost for resistin (?0.05 ± 0.04, p < 0.224) whereas adiponectin remained (?0.22 ± 0.07, p < 0.02) in low-BMD subjects. Adipsin, leptin and lipocalin-2 showed no significant associations. Findings of the present study revealed that only adiponectin showed a significantly strong inverse association with low BMD, suggesting that insulin sensitivity may influence bone health in Arab postmenopausal women. |
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Keywords: | Adipocytokines Osteoporosis/Osteopenia Saudi postmenopausal women |
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