Nephroprotective effect of pigmented violacein isolated from Chromobacterium violaceum in wistar rats |
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| Authors: | Lei Pang Paulrayer Antonisamy Galal Ali Esmail Abdulaziz Fahad Alzeer Naif Abdullah Al-Dhabi Mariadhas Valan Arasu Karuppiah Ponmurugan Young Ock Kim Hyungsuk Kim Hak-Jae Kim |
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| Affiliation: | 1. The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, China;2. Ilwonbio Co., Ltd., Department of Physiology, Wonkwang University School of Korean Medicine, Iksan, Jeonbuk, South Korea;3. Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia;4. Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea;5. Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea |
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| Abstract: | The present study aimed to analyze the nephroprotective property of violacein obtained from the bacterium, Chromobacterium violaceum. The nephrotoxicity in the animal model was induced by gentamicin, potassium dichromate, mercuric chloride, and cadmium chloride-induced nephrotoxicity in the Wistar rats was analyzed by measuring the serum creatinine, uric acid, and urea level. The present investigation revealed the nephroprotective property on convoluted proximal tubule (S1 and S2 segments) and the straight proximal tubule (S3 segment). Also, violacein significantly improved the renal function by the renal protective property on S2 segment of proximal tubule from the nephrotoxicity stimulated by mercuric chloride, potassium dichromate, cadmium chloride and gentamicin in animal models. Animal model studies revealed that violacein at 20 and 40 mg/kg p.o improved the renal function and significantly reduced the increased amount of uric acid, creatinine, and blood urea compared to the control. |
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| Keywords: | Violacein Creatinine Gentamicin Nephroprotective property |
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