Eco-friendly synthesis of silver nanoparticles from the whole plant of Cleome viscosa and evaluation of their characterization,antibacterial, antioxidant and antidiabetic properties |
| |
Authors: | Suresh Yarrappagaari Rajasekar Gutha Lohitha Narayanaswamy Lavanya Thopireddy Lakshminarsimhulu Benne Syed Siraj Mohiyuddin V Vijayakumar Rajeswara Reddy Saddala |
| |
Institution: | 1. Division of Ethnopharmacology, Department of Biotechnology, School of Herbal Studies and Naturo Sciences, Dravidian University, Kuppam 517 426, Andhra Pradesh, India;2. Centre for Organic and Medicinal Chemistry, VIT University, Vellore 632 014, Tamil Nadu, India;3. Department of Zoology, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India |
| |
Abstract: | The current research is to develop an easy and eco-friendly method for the synthesis of three different concentrations of silver nanoparticles (1mMCvAgNPs, 2mMCvAgNPs and 3mMCvAgNPs) using aqueous whole plant extract of Cleome viscosa and to evaluate their antibacterial, antioxidant and antidiabetic properties. CvAgNPs were characterized by Using UV–vis spectrophotometer, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM) and transmission electron microscope (TEM). The formation of CvAgNPs was confirmed by the observation of band between 250 nm to 600 nm UV–vis spectrum. The crystalline structure of CvAgNPs with a face-centered cubic (FCC) was confirmed by XRD. The responsible phytochemicals for the reduction and capping material of CvAgNPs were observed with FT-IR. The SEM analysis confirmed the size and shapes of CvAgNPs. The CvAgNPs have shown the rich content of total phenolic and total flavonoid components. The CvAgNPs have shown significant antibacterial activity on multi drug resistance Gram-negative and Gram-positive bacteria and also have shown significant strong antioxidant activities (DPPH, ABTS, H2O2 scavenging, Phosphomolybdenum assay and reducing power). The inhibitory action of CvAgNPs on α-glucosidase and α-amylase was stronger than the inhibitory action of acarbose. To best of our knowledge, this is the first attempt on the synthesis of AgNPs using C. viscosa whole plant aqueous extract. The synthesized CvAgNPs exhibited good antimicrobial, antioxidant and antidiabetic properties. Hence, to validate our results, the in vivo studies at the molecular level are needed to develop Cleome viscosa as an antibacterial, antioxidant and anti-diabetic agent. |
| |
Keywords: | XRD SEM TEM Antibacterial Antioxidant Antidiabetic |
本文献已被 ScienceDirect 等数据库收录! |
|