Paecilomyces tenuipes extracts affect lipid and glucose metabolic parameters similarly to Cordyceps militaris extracts |
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| Institution: | 1. College of Natural Resources and Life Science, Dong-A University, Busan 49315, Republic of Korea;2. OK Bio Lab, Seongnam 13207, Republic of Korea;1. Department of Biological Sciences, Faculty of Science, King Faisal University, Hofouf 31982, Al-Ahsa, Saudi Arabia;2. Department of Zoology and Entomology, Faculty of Science, Assiut University, Assiut, Egypt;3. Department of Zoology, Faculty of Science, Al-Azhar University, Cairo 11884, Egypt;4. Department of Zoology, Faculty of Science, Alexandria University, Alexandria 21511, Egypt;1. Department of Agricultural Biotechnology, College of Agriculture & Life Science, Seoul National University, Seoul 08826, Republic of Korea;2. Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea;1. Department of Biological Environment, Faculty of Bioresource Sciences, Akita Prefectural University, Shimoshinjyo-Nakano, Akita 010 0915, Japan;2. Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake–cho, Sakyo–ku, Kyoto 606 8502, Japan;1. Organization for Promotion of Tenure Track, University of Miyazaki, Miyazaki, Japan;2. Entomology Research Museum, Department of Entomology, University of California, Riverside, CA 92521, USA;3. Okinawa Prefectural Agricultural Research Center, Makabe, Itoman, Okinawa, Japan |
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| Abstract: | Ascocarps of some species of the genus Cordyceps have long been used as a traditional medicine and food source for promoting human health. The compound cordycepin, isolated from C. militaris ascocarps (CE), show similar health effects to CE. In this study, we investigated and compared the anti-obesity and antidiabetic effects of dietary CE and Paecilomyces tenuipes ascocarps (PE) in mice. In addition, we investigated their effects on the expression of genes related to the regulation of obesity and diabetes. We found that dietary CE and PE suppressed body weight gain and fat accumulation in the liver and adipocyte tissues of mice fed a high-fat diet (HFD). Enzyme and lipid profiles induced by HFD returned to normal with CE or PE treatment. Dietary CE or PE reduced fasting blood glucose and serum insulin levels in HFD-fed mice. Finally, we show that CE and PE treatment restored to normal the hyperlipidemia- and hyperglycemia-related gene expressions in HFD-fed mice. These results indicate that dietary CE or PE exert their anti-obesity and antidiabetic effects by regulating adipogenesis and insulin signaling pathways. Finally, we show that dietary CE or PE have similar anti-obesity and antidiabetic effects even when included in a normal mouse diet. Although cordycepin is not found in PE, PE treatment improves lipid and glucose metabolic parameters in a manner similar to CE. We find that PE provides alternative potential therapeutic treatments for obesity and diabetes. |
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| Keywords: | High-fat diet Metabolic parameter Antiobesity |
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