The Role of MicroRNA-155 in Chlamydia muridarum Infected lungs |
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| Institution: | 1. Department of Histology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran;2. Infectious Diseases and Tropical Medicine Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran;3. Department of Anatomy, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran;4. Department of Gynecology and Obstetrics, Pregnancy Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran;5. Department of Gynecology and Obstetrics, Yasuj University of Medical Sciences, Yasuj, Iran;1. Laboratory for Reproductive Medicine and Immunology, 7013 Realm Dr, Ste A, San Jose, CA, USA;2. Stanford University, Human Immune Monitoring Center, CCSR 0128, 1291 Welch Road, Stanford, CA, USA;1. Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, 6020, Innsbruck, Austria;2. Department of Microbiology and Immunology, McGill University, Montréal, H3A 0G4, Canada;3. Department of Anesthesiology and Critical Care Medicine, 6020, Innsbruck, Austria;1. Department of Parasitology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil;2. Department of Physics, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil;3. School of Medical Sciences, Universidade Federal de Mato Grosso, Cuiabá, MT, 78060-900, Brazil |
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| Abstract: | Our laboratory has investigated the role of an evolutionarily conserved RNA species called microRNAs (miRs) in regulation of anti-chlamydial protective immunity. MiRs including miR-155 expressed in specific immune effector cells are critical for antigen specific protective immunity and IFN-γ production. Using miR-155 deficient mice, and a murine pulmonary model for chlamydial infection, we report here 1) the effect of host miR-155 on bacterial burden, and 2) identify probable immune genes regulated by miR-155. |
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| Keywords: | microRNA miR-155 Lung Bacterial burdens Gene regulation IFN-γ |
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