Endogenous granulocyte colony-stimulating factor: a biomarker in acute ischemic stroke |
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Authors: | Yu Shih-Chieh Kuo Chen-Ling Huang Ching-Shan Chang Cheng-Shu Wu Shey-Lin Su Shih-Li Liu Chin-San |
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Affiliation: | Department of Neurology, Kuang-Tien General Hospital, Taichung, Taiwan. |
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Abstract: | Granulocyte colony-stimulating factor (G-CSF) may protect ischemic brain injury either in animal or human. No studies have reported that endogenous G-CSF (enG-CSF) level is related to the severity of ischemic stroke. This study was designed to assess the severity of ischemic patients correlated with the alteration of enG-CSF on the 1st day after an ischemic event. Patient's plasma enG-CSF and scoring of National Institute of Health Stroke Scale were measured on the 1st day after ischemic stroke. The acute ischemic stroke could significantly induce enG-GCF secretion as compared with healthy control group (16.77 vs. 22.86 μg/L, p = 0.001). Elevated enG-CSF concentration was positively correlated with the severity of stroke patients on day 1 after the event (p = 0.006; Spearman correlation coefficient = 0.268). The enG-CSF is a good biomarker for prediction of severity of acute ischemic stroke. |
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