LRRK2 as a modulator of lysosomal calcium homeostasis with downstream effects on autophagy |
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Authors: | Gómez-Suaga Patricia Hilfiker Sabine |
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Institution: | Institute of Parasitology and Biomedicine López-Neyra, Consejo Superior de Investigaciones Cientificas (CSIC), Granada, Spain. |
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Abstract: | Alterations in autophagy are thought to underlie various neurodegenerative diseases including Parkinson disease (PD). Previous studies have indicated that the PD gene leucine rich repeat kinase 2 (LRRK2) is involved in this process, but its mechanism of action has remained unknown. Our recent work describes how LRRK2 acts through calcium-mediated events originating from acidic stores to regulate autophagy and cell survival, which may give rise to novel therapeutic strategies. |
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