SLO,SLO, quick,quick, slow: calcium-activated potassium channels as regulators of <Emphasis Type="Italic">Caenorhabditis elegans</Emphasis> behaviour and targets for anthelmintics |
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Authors: | Lindy Holden-Dye Vincent O’Connor Neil A Hopper Robert J Walker Achim Harder Kathryn Bull Marcus Guest |
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Institution: | (1) School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK;(2) Bayer HealthCare AG, BHC-AH-RD-CRD-PARA, 6700 Monheim, Germany |
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Abstract: | Large-conductance calcium and voltage-activated potassium channels, termed SLO-1 (or BK), are pivotal players in the regulation
of cell excitability across the animal phyla. Furthermore, emerging evidence indicates that these channels are key mediators
of a number of neuroactive drugs, including the most recent new anthelmintic, the cyclo-octadepsipeptide emodepside. Detailed
reviews of the structure, function and pharmacology of BK channels have recently been provided (Salkoff et al. in Nat Rev
Neurosci 7:921–931, 2006; Ghatta et al. in Pharmacol Ther 110:103–116, 2006) and therefore these aspects will only briefly be covered here. The purpose of this review is to discuss how SLO-1 channels
might function as regulators of neural transmission and network activity. In particular, we focus on the role of SLO-1 in
the regulation of Caenorhabditis elegans behaviour and highlight the role of this channel as an effector for pleiotropic actions of neuroactive drugs, including emodepside.
On the premise that C. elegans is a ‘model nematode’ with respect to many aspects of neural function, the intention is that this might inform a broader
understanding of the role of these channels in the nematodes and their potential as novel anthelmintic targets. |
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Keywords: | BK channels Anthelmintics C elegans SLO-1 Nematode |
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