Genetic control of susceptibility to experimental allergic encephalomyelitis in mice |
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Authors: | Zeev Lando Dvora Teitelbaum Ruth Arnon |
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Institution: | (1) The Weizmann Institute of Science, Rehovot, Israel |
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Abstract: | The genetic control of susceptibility to experimental allergic encephalomyelitis (EAE) was studied in mice. The results indicate that sensitivity to disease is not inherited in a simple Mendelian dominant way. Susceptibility to EAE is governed by genes located outside of the major histocompatibility complex and not byH-2-linkedIr genes. No correlation was observed between susceptibility to disease and the cellular immune response toward the small encephalitogenic protein. |
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