Inhibition of 5-aminolevulinic acid (ALA) dehydratase by undissociated levulinic acid during ALA extracellular formation by Rhodobacter sphaeroides |
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| Authors: | Ken Sasaki Masanori Watanabe Naomichi Nishio |
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| Institution: | (1) Chemistry Laboratory, Hiroshima-Denki Institute of Technology, Nakamo, Akiku Hiroshima 739-03, Japan;(2) Department of Fermentation Technology, Faculty of Engineering, Hiroshima University, Kagamiyama Higashi-Hiroshima 739, Japan |
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| Abstract: | The inhibition of ALA dehydratase by levulinic acid during ALA extracellular formation of Rhodobacter sphaeroides correlated
with the concentration of undissociated form of levulinic acid irrespective of culture pH. The inhibition constant, Ki, of
intracellular ALA dehydratase by Dixon plots was 2.95 μM. Undissociated levulinic acid therefore functions as an inhibitor
of ALA dehydratase.
This revised version was published online in November 2006 with corrections to the Cover Date. |
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