兔肾性高血压时的动脉压力感受器反射

14只雄性家兔在双肾缩扎术后12周,经氨基甲酸乙酯静脉麻醉,分别在缓冲神经完整、切断两侧减压神经或切断两侧窦神经后静注新福林或硝普钠升降血压以改变动脉压力感受器活动,观察其心率、后肢血管阻力和肾交感神经活动的反射性变化,并与正常血压兔的反射效应相比较。主要结果如下:(1) 动物双肾动脉缩扎后12周,平均动脉血压(131±9mmHg)较正常动物血压(95±10mmHg)有显著升高(P<0.001);(2) 缓冲神经完整时,新福林和硝普钠升降血压诱发的心率反射性变化与正常血压动物相比显著减弱(P<0.001),而后肢血管阻力和肾交感神经活动的反射性调节无明显改变,表明肾性高血压动物的心率反射性调节与外周循环的反射性调节机能不相平行;而由股动脉内直接注射新福林或硝普钠时,股动脉灌流压的增减幅度与正常血压动物相比并无明显差异;(3) 切断两侧减压神经或切断两侧窦神经后,在正常动物仅使反射性心率调节作用减弱,而后肢血管阻力和肾交感神经活动的反射性调节无明显改变;但在高血压动物,除心率的反射性调节进一步减弱外,新福林和硝普钠升降血压时后肢血管阻力和肾交感神经活动的反射性调节效应也显著地减弱(P<0.001),提示肾性高血压时动脉压力感受器反射的潜在调节能力降低。由此似表明,肾性高血压时动脉压力感受器反射

ARTERIAL BAROREFLEX IN THE RENAL HYPERTENSIVE RABBITS

In 14 anesthetized male rabbits subjected bilateral renal wrapping 12 weeks before, the baroreflex control of heart rate (HR), hindlimb vascular resistance (HVR) and renal sympathetic nerve activity (RSNA) was examined during arterial baroreceptor loading and unloading by injecting phenylephrine (PE) and nitroprusside (NP). The results were as follows: (1) The mean arterial pressure (131 +/- 9 mmHg) of the kidney-wrapped rabbits was significantly higher than that (95 +/- 10 mmHg) of the control rabbits (P less than 0.001). (2) With the buffer nerves intact, the baroreflex control of HR was obviously impaired in the hypertensive rabbits (P less than 0.01), whereas the reflex control of HVR and RSNA remained unchanged as compared with the normotensive rabbits (P greater than 0.05), indicating a dissociation of baroreflex control of HR from that of peripheral circulation. However, in response to local intraarterial injection of PE and NP, the changes in HVR showed no difference between the hypertensive and normotensive rabbits. (3) After aortic or carotid baroreceptor denervation, the reflex control of HR was further reduced in the hypertensive rabbits, and the reflex control of HVR and RSNA was also significantly reduced (P less than 0.01), suggesting an impairment of potential baroreflex regulation of the circulation. It is likely that the changes of baroreflex in hypertensive rabbits may be attributed to the abnormalities in both baroreceptor and central integrating mechanism.