内皮素在休克中的发病学意义

内皮素是新近发现的血管内皮细胞产生的一种生物活性多肽,本工作用特异性放免法测定发现晚期败血症休克病人血浆内皮素水平显著增加;给健康大鼠持续滴注内皮素即能复制出典型休克模型(Endothelin-shock);给失血性休克大鼠滴注小剂量内皮素则恶化休克促进其不可逆发展。实验结果提示内皮素可能是机体的内源性致损伤因子,是参与休克发生发展的重要体液因素之一。

SIGNIFICANCE OF ENDOTHELIN IN SHOCK PATHOGENESIS

Endothelin is a recently discovered bioactive peptide produced by vascular endothelial cells. By means of specific radioimmunoassay we found that plasma endothelin level in patients with late septic shock was significantly increased. And a typical shock model in healthy rats was reproduced by continuous infusion of endothelin (endothelin shock). Infusion of endothelin at a small dose to hemorrhagic shocked rats deteriorated the shock process and resulted in an irreversible development. From these results it is suggested that endothelin may be an endogenous injury-inducing factor, acting as one of the important humoral factors involved in shock pathogenesis.