冠状动脉狭窄对血流量的影响

在22条开胸犬上观察了冠脉狭窄对血流量(CBF)的影响。用一可调节的微米缩窄器定量调节左旋支缩窄程度,测量了主动脉平均压(Pa)、冠脉远端小动脉平均压(Pc)和狭窄端压力降(ΔP)。冠脉狭窄程度与血流量变化曲线显示:在冠脉狭窄程度小于85％时,CBF相对稳定;随着狭窄程度的进一步增加,CBF急剧下降;而在狭窄程度大于95％后,CBF又缓慢下降。冠状动脉狭窄程度与CBF下降的曲线可用下列方程式表达: CBF=1.48×10~(10)e~(-27.6A)(A=冠脉狭窄程度) 冠脉狭窄程度大于50％时,狭窄程度与Pc呈负相关:Pc=159.1—1.36A(r=-0.73,P<0.01)。Pc与CBF呈正相关;Pc=16.9 1.3CBF(r=0.74,P<0.01)

EFFECTS OF STENOSIS ON BLOOD FLOW IN THE CORONARY ARTERY OF DOGS

The effects of stenosis on coronary blood flow (CBF) were studied in 22 open-chest mongrel dogs. A progressive stenosis was produced by a micrometer constrictor on the left circumflex coronary artery. Mean aortic pressure (Pa), distal coronary pressure (Pc) and stenotic segment pressure drop (delta P) were measured. Curve of CBF versus % stenosis showed that CBF was relatively constant with stenosis less than 85%, CBF rapidly decreased with stenosis of 85-95%, and then slowly reduced as stenosis was further increased. The change in CBF versus % stenosis was expressed as follows: CBF = 1.48 X 10(10) theta -27.6 A (where A = % stenosis in lumen area). With progressive coronary artery stenosis (greater than 75%), the change in percent stenosis and Pc showed a negative correlation: Pc = 159.1-1.36A (r = -0.73, P less than 0.01); the change in Pc and CBF showed a positive correlation: Pc = 16.9 + 1.3 CBF (r = 0.74, P less than 0.01).