| 组胺H2受体拮抗剂对骨髓造血重建的影响 |
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| 引用本文： | 杜勋湘 徐有恒. 组胺H2受体拮抗剂对骨髓造血重建的影响[J]. 生理学报, 1989, 41(6): 597-601 |
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| 作者姓名： | 杜勋湘 徐有恒 |
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| 作者单位： | 湖南医科大学血液生理研究室(杜勋湘，周衍椒)，湖南医科大学血液生理研究室(徐有恒) |
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| 摘 要： | 用组胺H_2受体拮抗剂(甲氰咪胍或呋喃硝胺)处理正常和亚致死量γ-射线照射小鼠,探讨正常体内造血和再生骨髓中造血重建与组胺受体的关系。发现非毒性剂量的甲氰咪胍对正常小鼠骨髓多能造血干细胞(CFU-s)无抑制作用,但可抑制小鼠体内粒单系祖细胞(CFU-GM)的生长和亚致死量照射后CFU-s产率的恢复。组胺可能与骨髓的再生有关,组胺H_2受体拮抗剂可抑制骨髓的造血重建。
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| 关 键 词： | 组胺H_2受体拮抗剂 甲氰咪胍 亚致死量照射 造血重建 造血干细胞 |
EFFECTS OF HISTAMINE H_2-RECEPTOR ANTAGONISTS ON HEMOPOIETIC RECONSTRUCTION IN BONE MARROW |
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| DU XUN-XIANG,ZHOU YAN-JIAO AND XU YOU-HENG Laboratory f Experimental Hematology,Hunan Medical University Changsha,Hunan. EFFECTS OF HISTAMINE H_2-RECEPTOR ANTAGONISTS ON HEMOPOIETIC RECONSTRUCTION IN BONE MARROW[J]. Acta Physiologica Sinica, 1989, 41(6): 597-601 |
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| Authors: | DU XUN-XIANG ZHOU YAN-JIAO AND XU YOU-HENG Laboratory f Experimental Hematology Hunan Medical University Changsha Hunan |
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| Affiliation: | DU XUN-XIANG,ZHOU YAN-JIAO AND XU YOU-HENG Laboratory 0f Experimental Hematology,Hunan Medical University Changsha,Hunan |
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| Abstract: | The effects of histamine H2-receptor antagonists (cimetidine and ranitidine) on bone marrow hematopoiesis of normal and sublethally irradiated mice were investigated. It was found that non-toxic dosage of cimetidine had no significant effect on CFU-s of the normal mouse, but it inhibited CFU-GM growth with a dosage-dependent relationship and the recovery of CFU-s formation from sublethal gamma-ray irradiation. These results suggest that histamine may play a role in bone marrow regeneration after sublethal irradiation. Histamine H2-receptor antagonists can inhibit hemopoietic reconstruction in regenerating bone marrow. |
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| Keywords: | histamine H_3-receptor antagonists cimetidine sublethal irradiation hemopoietic reconstruction hematopoietic stem cells |
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