慢性颞叶癫痫大鼠行为、电图发作和核磁共振研究--海马-内嗅皮质-颞叶新皮质通路

目的和方法：强直电刺激（６０Ｈｚ,０．４￣０．６ｍＡ,２ｓ）左、右侧背侧海马或中部颞叶新皮质制作慢性大鼠癫痫模型,观察大鼠行为、ＥＥＧ、深部电图以及各脑区Ｔ２（质子横向驰豫时间）加权核磁共振成象（Ｔ２－ＭＲＩ）结构改变,研究海马－内嗅皮质－颞叶新皮质、大脑皮层神经通路在诱发颞叶癫痫中的可能作用。结果：右侧海马刺激组的原发性、继发性湿狗样抖动及癫痫“点燃”效应的发生率明显高于左海马和左、右颞叶新皮质

STUDIES ON BEHAVIORAL AND ELECTROGRAPHIC SEIZURES AND STRUCTURAL ABNORMALITIES USING MAGNETIC RESO-NANCE IMAGE IN CHRONIC EPILEPSY MODEL IN RATS--HIPPOCAMPAL-ENTORHINAL-TEMPRAL NEOCORTEX NEURAL PATHWAY

AIM AND METHODS: Repeated tetanus (60 Hz, 0.4-0.6 mA, 2 s) were delivered into the right and the left dorsal hippocampus (HPC), or into the right and the left medial temporal neocortex (MTNC) respectively to establish chronic temporal lobe epilepsy model in rats. The possible role of the HPC-Entorhinal cortex (EC)-MTNC-Neocortex neural pathway in epileptogenesis was discussed based on observing the abnormalities in behavior and in EEG or depth electrographes and in T2-weighted magnetic resonance images (T2-MRI). RESULTS: 1. Occurrence of primary, secondary WEDS and kindling effects were higher in the right dorsal HPC experimental group than those in other three experimental groups (P < 0.005, P < 0.001). T2-MRI signal hyperintensity was remarkable in lateral ventricles close to the HPC (P < 0.05), but not in the EC or in the MTNC. 2. These T2-MRI intensity increases were related to behavioral abnormalities in some MTNC-stimulated rats. 3. Asymmetric behavioral abnormalities and T2-MRI changes were observed in the left and the right DHPC-stimulated groups. CONCLUSION: HPC may be an "origin" for epileptogenesis and EC may play a "gating" role in it.