Detection of Coxiella burnetii specific DNA in blood samples from Japanese patients with chronic nonspecific symptoms by nested polymerase chain reaction |
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Authors: | Kimitoshi Kato Yasutomo Arashima Satoshi Asai Yumiko Furuya Yoshiya Yoshida Masato Murakami Yasuo Takahashi Kuniki Hayashi Takashi Katayama Kazunari Kumasaka Yasuyuki Arakawa Kinya Kawano |
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Affiliation: | Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK |
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Abstract: | Sprague Dawley rats, previously infected with Phase-I Bordetella pertussis , developed more severe abnormal respiratory sounds than normal animals, but not coughing, when exposed to aerosolized capsaicin, one of several cough-inducing agents tested. Stethoscope examination suggested that greater production of pulmonary mucus might be occurring after capsaicin challenge of the infected animals, compared to the uninfected controls. Rats of three other strains gave characteristically different responses from the Sprague Dawleys. The administration of capsaicin to B. pertussis -infected rats may provide useful insights into the pathophysiology of excess mucus secretion in human pertussis. |
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Keywords: | Bordetella pertussis Capsaicin Sprague Dawley rat Cough |
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