Founder mutations characterise the mutation panorama in 200 Swedish index cases referred for Long QT syndrome genetic testing |
| |
Authors: | Stattin Eva-Lena Boström Ida Maria Winbo Annika Cederquist Kristina Jonasson Jenni Jonsson Björn-Anders Diamant Ulla-Britt Jensen Steen M Rydberg Annika Norberg Anna |
| |
Institution: | 1. Institute of Health and Society, University of Oslo, Oslo, Norway 2. Norwegian Knowledge Centre for the Health Services, Oslo, Norway 3. Norwegian Institute of Public Health, Oslo, Norway 4. Department of Cardiology, Oslo University Hospital, Oslo, Norway 5. University of Bergen, Bergen, Norway
|
| |
Abstract: | Background Hypertension is one of the leading causes of cardiovascular disease (CVD). A range of antihypertensive drugs exists, and their prices vary widely mainly due to patent rights. The objective of this study was to explore the cost-effectiveness of different generic antihypertensive drugs as first, second and third choice for primary prevention of cardiovascular disease. Methods We used the Norwegian Cardiovascular Disease model (NorCaD) to simulate the cardiovascular life of patients from hypertension without symptoms until they were all dead or 100 years old. The risk of CVD events and costs were based on recent Norwegian sources. Results In single-drug treatment, all antihypertensives are cost-effective compared to no drug treatment. In the base-case analysis, the first, second and third choice of antihypertensive were calcium channel blocker, thiazide and angiotensin-converting enzyme inhibitor. However the sensitivity and scenario analyses indicated considerable uncertainty in that angiotensin receptor blockers as well as, angiotensin-converting enzyme inhibitors, beta blockers and thiazides could be the most cost-effective antihypertensive drugs. Conclusions Generic antihypertensives are cost-effective in a wide range of risk groups. There is considerable uncertainty, however, regarding which drug is the most cost-effective. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|