Exon duplication from a fork head to a homeodomain protein |
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Authors: | T R Bürglin Gudrun Aspöck |
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Institution: | (1) Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland E-mail: burglin@ubaclu.unibas.ch Tel.: +41-61-2672066, Fax: +41-61-2672078, CH |
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Abstract: | The evolution of complex organisms such as animals requires a large expansion of the number of genes controlling developmental
events. In addition, it is thought that domains are shuffled between genes to further increase the complexity and generate
new types of genes and functions. Working with the Caenorhabditis elegans homeobox gene ceh-43, the orthologue of fly Distal-less (Dll), we observed sequence similarity to the C. elegans gene fkh-1. Now, with the complete genomic sequence available, we examined this similarity in detail. The region of similarity is confined
essentially to one exon in the carboxy terminus of the two genes. Based on the gene structure, we think that an exon of fkh-1 was duplicated to the carboxy terminus of ceh-43, where it was incorporated as the last exon. This duplication event seems to have happened recently since the similarity
on the nucleotide level is higher than the sequence similarity between fkh-1 of C. elegans and C. briggsae. Potentially the duplication event was mediated via a short region of sequence similarity between the two open reading frames
of the genes. This duplication event clear shows that a part of a gene can successfully be juxtaposed to another gene. These
events may perhaps not be rare.
Received: 28 March 1999 / Accepted: 8 June 1999 |
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Keywords: | Exon duplication Homeobox gene Fork head gene Winged helix C elegans |
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