Structure-function relationships amongLathyrus lectins |
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| Authors: | Pierre Rougé Carl A K Borrebaeck Michael Richardson Alan Yarwood |
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| Institution: | (1) Laboratoire de Biologie cellulaire, Faculté des Sciences Pharmaceutiques, Université Paul Sabatier, 35 chemin des Maraîchers, 31 062 Toulouse, France;(2) Department of Biotechnology, University of Lund, P.O. Box 124, S-221 00 Lund, Sweden;(3) Department of Botany, University of Durham, DH1 3LE Durham, England |
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| Abstract: | The structure-function relationship of eight structurally very similarLathyrus lectins, which are two-chain lectins from theVicieae tribe, has been studied. Hemagglutination activity, inhibition of hemagglutination, glycoprotein reactivity and mitogenic activity were determined for each of the lectins. Despite the close structural resemblance, marked differences in the carbohydrate binding activity of theLathyrus lectins were recorded. These functional differences were related to small conformational changes due to minor differences in amino acid sequence of eachLathyrus lectin. |
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| Keywords: | Lathyrus lectin/isolectins structure-function relationship amino acid sequences blood group specificity inhibition by sugars interaction with hman serum glycoproteins mitogenicity |
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