Basic Fibroblast Growth Factor Prevents the Memory Impairment Induced by Gastrin-Releasing Peptide Receptor Antagonism in Area CA1 of the Rat Hippocampus |
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| Authors: | Thales Preissler Tatiana Luft Flávio Kapczinski João Quevedo Gilberto Schwartsmann Rafael Roesler |
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| Affiliation: | (1) Department of Pharmacology, Institute for Basic Health Sciences, Cellular and Molecular Neuropharmacology Research Group, Federal University of Rio Grande do Sul, 90046-900 Porto Alegre, RS, Brazil;(2) Department of Biochemistry, Institute for Basic Health Sciences, Graduate Program in Biochemistry, Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil;(3) Bipolar Disorders Program, Academic Hospital Research Center, Faculty of Medicine, Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil;(4) Department of Medicine, Laboratory of Neurosciences, University of Southern Santa Catarina, 88806-000 Criciuma, SC, Brazil;(5) Department of Internal Medicine, Faculty of Medicine, Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil;(6) Cancer Research Laboratory, Academic Hospital Research Center, Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil |
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| Abstract: | Increasing evidence indicates that the gastrin-releasing peptide receptor (GRPR) is implicated in regulating synaptic plasticity and memory formation in the hippocampus and other brain areas. However, the molecular mechanisms underlying the memory-impairing effects of GRPR antagonism have remained unclear. Here we report that basic fibroblast growth factor (bFGF/FGF-2) rescues the memory impairment induced by GRPR antagonism in the rat dorsal hippocampus. The GRPR antagonist [D-Tpi6, Leu13 psi(CH2NH)-Leu14] bombesin (6–14) (RC-3095) at 1.0 μg impaired, whereas bFGF at 0.25 μg enhanced, 24 h retention of inhibitory avoidance (IA) when infused immediately after training into the CA1 hippocampal area in male rats. Coinfusion with an otherwise ineffective dose of bFGF blocked the memory-impairing effect of RC-3095. These findings suggest that the memory-impairing effects of GRPR antagonists might be partially mediated by an inhibition in the function and/or expression of neuronal bFGF or diminished activation of intracellular protein kinase pathways associated with bFGF signaling. |
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| Keywords: | Gastrin-releasing peptide receptor Basic fibroblast growth factor RC-3095 Hippocampus Memory consolidation |
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