Relationship between contents of lipocalin-type prostaglandin D synthase on the surface of infertility sperm and in seminal plasma |
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| Authors: | De-Yu Chen Mao-Ying Zhu Ya-Dong Cui Tian-Hua Huang |
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| Institution: | (1) Research Center for Reproductive Medicine, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, 515041, Guangdong, China;(2) Department of Biology, Fuyang Normal College, Fuyang, 230632, China |
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| Abstract: | Lipocalin-type prostaglandin D synthase (L-PGDS) is localized in Leydig cells, sperm, and epithelial cells of the epididymis.
The present study was to determine the correlation between content of this enzyme in seminal plasma and on the surface of
sperm. We analyzed 90 semen samples. L-PGDS in seminal plasma was analyzed by an ELISA procedure. L-PGDS on sperm was analyzed
by flow cytometry. The semen donors were categorized in three groups: normal, oligospermic, and azoospermic. According to
results obtained, L-PGDS may have the ability to improve progressive motility of sperm, and L-PGDS in seminal plasma and on
sperm surface may impact male fertility in the female reproductive tract.
Published in Russian in Biokhimiya, 2007, Vol. 72, No. 2, pp. 255–259. |
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| Keywords: | lipocalin-type prostaglandin D synthase sperm infertility |
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