Modeling the evolution of a classic genetic switch |
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Authors: | Christos Josephides Alan M Moses |
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Institution: | (1) Departments of Cell & Systems Biology and Ecology & Evolutionary Biology, University of Toronto, 25 Willcocks Street, Toronto, ON, M5 S 3B2, Canada |
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Abstract: | Background The regulatory network underlying the yeast galactose-use pathway has emerged as a model system for the study of regulatory
network evolution. Evidence has recently been provided for adaptive evolution in this network following a whole genome duplication
event. An ancestral gene encoding a bi-functional galactokinase and co-inducer protein molecule has become subfunctionalized
as paralogous genes (GAL1 and GAL3) in Saccharomyces cerevisiae, with most fitness gains being attributable to changes in cis-regulatory elements. However, the quantitative functional implications of the evolutionary changes in this regulatory network
remain unexplored. |
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Keywords: | |
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