Production of teicoplanin from Actinoplanes teichomyceticus ID9303 by adding proline |
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| Authors: | Song Jung-Min Park Joon-Tae Lee Hong-Sub Kang Jae-Hoon Kang Dae-Jung |
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| Affiliation: | Research Laboratories, Ildong Pharmaceutical, Yongin 449-910, Korea. |
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| Abstract: | We evaluated the influence of amino acids in improving teicoplanin productivity. Arginine, lysine, and proline were selected for better productivity among 20 amino acids in Erlenmeyer flasks. Proline was finally chosen as the additive for maximum teicoplanin productivity in a 5-liter fermenter. We obtained the highest teicoplanin productivity, 3.12 g/l, on the eighth d in a 75-liter pilot fermenter. |
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