PROcEED: Probabilistic reverse dosimetry approaches for estimating exposure distributions

As increasing amounts of biomonitoring survey data become available, a new discipline focused on converting such data intoestimates of chemical exposures has developed. Reverse dosimetry uses a pharmacokinetic model along with measured biomarkerconcentrations to determine the plausible exposure concentrations-- a critical step to incorporate ground-truthing experimentaldata into a distribution of probable exposures that reduces model uncertainty and variability. At the population level, probabilisticreverse dosimetry can utilize a distribution of measured biomarker concentrations to identify the most likely exposureconcentrations (or intake doses) experienced by the study participants. PROcEED is software that provides access to probabilisticreverse dosimetry approaches for estimating exposure distributions via a simple user interface.

Availability

PROcEED along with installation instructions is freely available for download from http://www.epa.gov/heasd/products/proceed/proceed.html