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Rare,convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses
Institution:1. Antibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA;2. Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA;3. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA;4. Department of Biology, The Catholic University of America, Washington, DC 20064, USA;5. Integrated Research Facility, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA;6. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA;7. Integral Molecular, Philadelphia, PA 19104, USA;8. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA;9. Cellular Biology Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA;10. Protein Chemistry Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA;11. Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA;12. New York Blood Center, Lindsley F. Kimball Research Institute, New York, NY 10065, USA;13. Flow Cytometry Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA;14. B Cell Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA;15. The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Abstract:
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  • Keywords:SARS-CoV-2  COVID-19  betacoronavirus  variants of concern  monoclonal antibody  stem helix  broadly neutralizing antibodies
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