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Time-dependent and selective microglia-mediated removal of spinal synapses in neuropathic pain
Affiliation:1. Department of Pharmacology and Therapeutics, McGill University, Montréal, QC H3G 1Y6, Canada;2. Department of Anatomy and Cell Biology, McGill University, Montréal, QC H3A 0C7, Canada;3. Alan Edwards Centre for Research on Pain, McGill University, Montréal, QC H3A 2B4, Canada;4. Department of Anesthesia and Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montréal, QC H3G 1Y6, Canada;5. CERVO Brain Research Centre and Department of Psychiatry and Neuroscience, Université Laval, Québec, QC G1J 2G3, Canada
Abstract:
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  • Keywords:neuropathic pain  spinal cord  structural plasticity  microglia  synapse pruning  disinhibition  CP: Neuroscience
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