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Genetic and Antigenic Characterization of Enterovirus 71 in Ho Chi Minh City,Vietnam, 2011 |
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| Authors: | Le Phan Kim Thoa Pai-Shan Chiang Truong Huu Khanh Shu-Ting Luo Tran Ngoc Hanh Dan Ya-Fang Wang Tang Chi Thuong Wan-Yu Chung Nguyen Thanh Hung Jen-Ren Wang Le Nguyen Thanh Nhan Le Quoc Thinh Ih-Jen Su Than Duc Dung Min-Shi Lee |
| Affiliation: | 1. Children’s Hospital No. 1, Ho Chi Minh City, Vietnam.; 2. National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Taiwan.; 3. College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Johns Hopkins School of Public Health, United States of America, |
| Abstract: | Enterovirus 71 (EV71) frequently causes fatal infections in young children in Asia. In 2011, EV71 epidemics occurred in southern Vietnam. We conducted genetic and antigenic analysis of the EV71 isolates and found that 94% of them were genotype C4a related to two lineages circulating in China and 6% were genotype C5 which have circulated in Vietnam since 2003. Antigenic variants were not detected. EV71 vaccines are being developed. Longitudinal enterovirus surveillance data are critical to formulate vaccination policy in Vietnam. |
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