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Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME/CFS
Affiliation:1. Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA;2. Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY 10032, USA;3. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA;4. Division of General Medicine, Department of Medicine, Brigham and Women''s Hospital, Harvard Medical School, Boston, MA 02115, USA;5. Levine Clinic, New York, NY 10021, USA;6. Bateman Horne Center, Salt Lake City, UT 84102, USA;7. Institute for Neuro-Immune Medicine, College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL 33314, USA;8. Miami VA Medical Center, Miami, FL 33125, USA;9. Palo Alto Medical Foundation, Jack S. Remington Laboratory for Specialty Diagnostics of Toxoplasmosis, Palo Alto, CA 94301, USA;10. Sierra Internal Medicine at Incline Village, Incline Village, NV 89451, USA;11. Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Abstract:
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  • Keywords:myalgic encephalomyelitis/chronic fatigue syndrome  microbiome  butyrate  co-abundance network  irritable bowel syndrome  biomarkers  short-chain fatty acids  shotgun metagenomics  metabolomics
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