Long-term clinical observation of patients with acute and chronic complete spinal cord injury after transplantation of NeuroRegen scaffold |
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Authors: | Tang Fengwu Tang Jiaguang Zhao Yannan Zhang Jiaojiao Xiao Zhifeng Chen Bing Han Guang Yin Na Jiang Xianfeng Zhao Changyu Cheng Shixiang Wang Ziqiang Chen Yumei Chen Qiaoling Song Keran Zhang Zhiwei Niu Junjie Wang Lingjun Shi Qin Chen Liang Yang Huilin Hou Shuxun Zhang Sai Dai Jianwu |
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Affiliation: | 1.Characteristics Medical Center of the Chinese People’s Armed Police Forces (CAPF), Tianjin, 300162, China ;2.Fourth Medical Center of People’s Liberation Army (PLA) General Hospital, Beijing, 100048, China ;3.Department of Orthopaedics, Beijing Tongren Hospital, Beijing, 100730, China ;4.State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100190, China ;5.Beijing ZhongKeZaiKang Biotechnology Co., Ltd, Beijing, 101407, China ;6.Department of Rehabilitation, the 983rd Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army, Tianjin, 300141, China ;7.Department of Orthopaedics, the First Affiliated Hospital of Soochow University, Suzhou, 215006, China ; |
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Abstract: | Spinal cord injury (SCI) often results in an inhibitory environment at the injury site. In our previous studies, transplantation of a scaffold combined with stem cells was proven to induce neural regeneration in animal models of complete SCI. Based on these preclinical studies, collagen scaffolds loaded with the patients’ own bone marrow mononuclear cells or human umbilical cord mesenchymal stem cells were transplanted into SCI patients. Fifteen patients with acute complete SCI and 51 patients with chronic complete SCI were enrolled and followed up for 2 to 5 years. No serious adverse events related to functional scaffold transplantation were observed. Among the patients with acute SCI, five patients achieved expansion of their sensory positions and six patients recovered sensation in the bowel or bladder. Additionally, four patients regained voluntary walking ability accompanied by reconnection of neural signal transduction. Among patients with chronic SCI, 16 patients achieved expansion of their sensation level and 30 patients experienced enhanced reflexive defecation sensation or increased skin sweating below the injury site. Nearly half of the patients with chronic cervical SCI developed enhanced finger activity. These long-term follow-up results suggest that functional scaffold transplantation may represent a feasible treatment for patients with complete SCI. |
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