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Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor |
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| Authors: | Huang Xiaoxing Wang Youwang Yu Cong Zhang Hui Ru Qiang Li Xinxin Song Kai Zhou Min Zhu Ping |
| Institution: | 1.National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China ;2.The Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, 100193, China ;3.University of Chinese Academy of Sciences, Beijing, 100049, China ; |
| Abstract: | Science China Life Sciences - Human alpha-2-macroglobulin is a well-known inhibitor of a broad spectrum of proteases and plays important roles in immunity, inflammation, and infections. Here, we... |
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