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Single-copy locus proteomics of early- and late-firing DNA replication origins identifies a role of Ask1/DASH complex in replication timing control
Affiliation:1. Institute of Epigenetics and Stem Cells, Helmholtz Zentrum München, Feodor-Lynen-Strasse 21, 81377 München, Germany;2. Institute of Functional Epigenetics, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany;3. Institute of Computational Biology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany;4. Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Center for Environmental Health, Heidemannstrasse 1, 80939 München, Germany
Abstract:
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  • Keywords:locus-specific chromatin isolation  site-specific recombination  affinity purification  DNA replication origin  replication timing  replication efficiency  origin chromatin structure  DASH complex  Ask1 protein  microtubule cytoskeleton  CP: Molecular biology
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