TCTP Is an Androgen-Regulated Gene Implicated in Prostate Cancer |
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| Authors: | Mari Kaarb? Margrethe L Storm Su Qu H?kon W?hre Bj?rn Risberg H?vard E Danielsen Fahri Saatcioglu |
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| Institution: | 1. Department of Biosciences, University of Oslo, Oslo, Norway.; 2. Institute for Medical Informatics, Oslo University Hospital, Oslo, Norway.; 3. Division of Pathology, Oslo University Hospital, Oslo, Norway.; 4. Center for Cancer Biomedicine, Oslo University Hospital, Oslo, Norway.; 5. Department of Informatics, University of Oslo, Oslo, Norway.; Queensland University of Technology, Australia, |
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| Abstract: | TCTP has been implicated in a plethora of important cellular processes related to cell growth, cell cycle progression, malignant transformation and inhibition of apoptosis. In addition to these intracellular functions, TCTP has extracellular functions and plays an important role in immune cells. TCTP expression was previously shown to be deregulated in prostate cancer, but its function in prostate cancer cells is largely unknown. Here we show that TCTP expression is regulated by androgens in LNCaP prostate cancer cells in vitro as well as human prostate cancer xenografts in vivo. Knockdown of TCTP reduced colony formation and increased apoptosis in LNCaP cells, implicating it as an important factor for prostate cancer cell growth. Global gene expression profiling in TCTP knockdown LNCaP cells showed that several interferon regulated genes are regulated by TCTP, suggesting that it may have a role in regulating immune function in prostate cancer. In addition, recombinant TCTP treatment increased colony formation in LNCaP cells suggesting that secreted TCTP may function as a proliferative factor in prostate cancer. These results suggest that TCTP may have a role in prostate cancer development. |
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